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It is the acetylated form of l-carnitine, which is a brain-specific carnitine that crosses the blood-brain barrier
Interestingly, one key output of the AMPK/CRTC pathway is the modulation of mitochondrial structure and function, which NHR-49 may influence both indirectly via its impact on fatty acid catabolism, and directly, as NHR-49 cooperates with NHR-66 to affect mitochondrial morphology (Pathare et al., 2012)
