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It can lead to the formation of DNA-protein cross-links, single- and double-strand breaks, base damage, lipid peroxidation and protein fragmentation [31,32] (Figure 3)

Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

Structure-Reactivity Correlations for the Thiol-Disulfide Interchange Reaction

This compound not only inhibited SARM1s NADase activity effectively but also exhibited a favorable safety profile, making it a strong candidate for further development 233