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An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the proteinprotein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75
Mindfulness, cognitive behavioral therapy (CBT), or sex therapy can be used alongside peptides

doi:10.1074/jbc.275.12.8982 pmid:10722747 Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond
