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Development 149 , dev200394 (2022)

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

Most studies focus on the direct involvement of ubiquitination and deubiquitination in metabolic enzymes, which provides potential for jointly developing ubiquitin inhibitors and metabolic enzyme inhibitors

The actual pharmacokinetics of methionine, choline, and inositol suggest that timing flexibility exists as long as two conditions are met: the injection occurs in a fasted state, and the timing aligns with the patient's primary metabolic activity window