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Though the disruption of cytosolic cysteine metabolism (i.e., GSH synthesis) plays a significant role in the induction of ferroptosis under cysteine limitation 5,19 , it remains unknown if alterations in mitochondrial cysteine metabolism are also operative

NO is efficiently converted into low-molecular-weight SNOs (e.g., S-nitrosoglutathione [GSNOs]), which convey the large part of NO bioactivity

PLoS One (2012) 7(2):e31610.10.1371/journal.pone.0031610 72 SadeghiONasiriMMaghsoudiZPahlavaniNRezaieMAskariG

Figure 3 PRMT5 methylation has been identified as an important regulating process for the DNA damage repair pathways