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demonstrated that sulforaphane, in an Nrf2-dependent manner, protected against nigral dopaminergic cell death, astrogliosis and microgliosis in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) subacute mouse model of PD 27

The GPX4-GSH axis The antioxidant function of GSH is largely executed through GPXs and PRDXs, which catalyze reductive detoxification of lipid peroxidation 93

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In fact, selenite, the most common form of dietary inorganic selenium, is rapidly transformed to selenide and enters this metabolic pathway directly through that selenide door. One can understand that it is then rapidly incorporated in the seleno-cysteinyl moiety and activates Se-GSH-Px