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Conversely, brain IR, less recognized but equally important, pertains to impaired insulin signaling in neuronal and glial cells [6]

A summary of the representative BAPPs evaluated in clinical trials is presented in Table 2

Prolonged use of Vitamin B6 (over 2 months) at high doses exceeding 1g/day can lead to severe peripheral neuropathy, with symptoms including unsteady gait and numbness in the hands and feet

Once consumed, this nutrient is stored in the liver
