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Description
In energy deprived state, AMPK and SIRT1 regulate PGC-1 through phosphorylation and deacetylation, respectively [61]
Paraquat resistance assay Adult wt worms were allowed to lay eggs on LB or DB NGM plates
Up to respectively 70 and 40 M, AQ or DEAQ did not significantly activate any of the tested stress response pathways, which is consistent with the limited onset of cytotoxicity by these compounds ( Figure 2 )
All available (medical) treatment modalities to date are aimed at normalizing serum IGF-1 levels via reduction of either GH overproduction or GH actions [29-32]
