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A peroxisomal disorder of severe intellectual disability, epilepsy, and cataracts due to fatty acyl-CoA reductase 1 deficiency

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GPX4, a crucial oxidoreductase, is essential for removing lipid peroxidation products by using GSH as a reducing agent [107]

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Namely, apoA5 accelerated TRL hydrolysis, TRL remnants uptake by liver while inhibited hepatic TG secretion [1, 49] (Fig

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