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Acta Physiol (Oxf) 216:4289

Cimmino L, Dolgalev I, Wang Y et al (2017) Restoration of TET2 function blocks aberrant self-renewal and leukemia progression

In a given multicenter trial, 11 percent of sites fail to enroll a single patient, 37 percent of sites do not meet enrollment targets, and studies are typically lengthened (often to double the original timeline) to satisfy enrollment targets [3]thereby constituting a significant use of resources to launch clinical trials that fail or struggle to reach the desired return on that investment

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