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glutathione s-transferase alpha 1 Frontiers Glutathione transferases: substrates, inihibitors and
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Prior to excretion, SN-38 is sent to the liver where uridine diphosphate glucuronosyltransferase (UGT) enzymes attach a glucuronide group to the SN-38 scaffold, converting it to the inactive metabolite SN-38-glucuronide (SN-38-G), which is non-toxic

IRS-1 is an adaptor protein that provides a binding site for PI-3 kinase, whose activation stimulates Akt ( Figure 2 )
