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Description
In another embodiment the ligand is a ligand that is endocytosed and/or transcytosed into and/or through the target cell as may be assayed by a cell culture model of the BBB (using primary isolated bovine brain capillary endothelial cells (BCEC)) as described by Gaillard et al
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In contrast, CHAC1-driven GSH degradation reduces protein SSG, enhances transferrin receptor (TFRC)mediated iron uptake, and exacerbates ferroptosis, whereas hemoglobin SSG shields reactive cysteine residues from excessive oxidation 127,128
10.1002/ajmg.a.32589 102 WuJ.JiangZ.HuangX.LuoZ.PengH
