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B12 plays a crucial role in energy production, brain function, red blood cell formation, and nervous system health

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Among various alkylating agents, N-ethylmaleimide is identified as the most reliable for thiol stabilization in liquid chromatographymass spectrometry (LC-MS) workflows, while specific reagents such as monobromobimane or -(4-hydroxyphenyl)ethyl iodoacetamide (HPE-IAM) are required for persulfide and polysulfide detection

Conclusions Our findings demonstrate that screening potential natural products through an AD-related pathway-gene network is a promising strategy for discovering novel therapeutics for AD