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Results Elevated dependence on extracellular glutamine and cystine in TNBC cells To investigate the dependence of breast cancer (BC) cells on glutamine (Gln), we first assessed cell proliferation under Gln deprivation and the sensitivity to the glutaminase (GLS1) inhibitor CB839 in luminal BC cell lines (CAMA-1, ZR-75-1, T47D, and MCF7) and TNBC cell lines (MDA-MB-231, SUM159, Hs578T, and its invasive subclone Hs578Ts(i) 8 ) after 72 h of culture (Fig

While there is limited research specifically addressing the safety of this combination, we can look at the individual properties of both substances to draw some conclusions

Cell 49 , 186199 (2013)