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Vertebrate animal models Toxin-induced models Quinolinic acid (QA) model Quinolinic acid selectively targets medium spiny neurons (MSNs) in the striatum, mimicking HDs excitotoxic mechanisms (Ca 2 dysregulation, ATP depletion) and manifesting an early-stage hyperkinetic symptoms (Bordelon et al

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These findings were further supported by the analysis of the trends with mAUC, which showed no statistically significant difference between groups (p fT3 = 0.147 and p fT4 = 0.132) (Supplementary Figures S3a and S4a)

10.1016/j.theriogenology.2020.06.029 172 Shabajee-AlibayP.BonnaudA.MalpauxB.DelagrangeP.AudinotV.YousS.et al (2022)