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( e ) FT282-CCNE1 cells transduced with shRNA targeting CrAT, CrOT, or TMLHE (shTMLHE) were incubated with 13 C 6 -glucose, and glucose-derived M + 2 acetyl-CoA was assessed (n = 8 technical replicates representative from 2 independent experiments)

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Taken together with AC/FC reduction by HF treatments in this study, carnitine metabolic changes might be not only distinct prognostic biomarkers, but also be therapeutic targets for HF

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