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The HPV16 E7 oncoprotein directly suppresses the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, significantly reducing the expression of genes that encode type I interferon and pro-inflammatory proteins, hence facilitating immune evasion in several HPV-related tumors in murine models (Luo et al., 2020)

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Biodistribution Cy 5.5-labeled ZFPG NPs were injected into the tail vein of PC-3 tumor-bearing male nude mice, and fluorescence imaging was performed on mice in the Control (PBS), ZFPG, and ZFPG + MF group at different time points through the IVIS Spectrum system (PerkinElmer), respectively

All GCT enzymes possess a highly conserved pocket, proposed to be the active site, which contains a catalytically relevant glutamate residue