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There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions

A short pharmacological interruption of the RA signaling in adult mice leads to a decrease in airway function, an increase in airway smooth muscles (ASM) thickness, and collagen disposition, resulting in ASM hypertrophy and airway remodeling [228,229]

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