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Higher concentration: mixing to ~5,000 mcg/mL keeps injection volumes small even when dosing 500750 mcg twice daily
In addition, transcriptomic analysis of brains of 2 independent SCA3 transgenic mouse models reported downregulation of genes involved in glutamatergic and alpha-adrenergic neurotransmission and alterations in CREB pathways, as well as in axon guidance molecules, some of these alterations being already present at presymptomatic ages [117, 122]
doi: 10.1097/01.ogx.0000279291.86611.46
Calling a format buccal or lipid-based does not demonstrate that an intact peptide reaches circulation in a meaningful amount
