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Although methylenedioxyphenyl compounds can form glutathione conjugates via quinone intermediates, no such adducts were detected across any of the four species, likely reflecting effective detoxification of the catechol metabolite M1 through competing phase II pathways including O -methylation, sulfation, and glucuronidation 33

Lastly, the models were trained and tested on American and Caucasian-skewed cohorts, and future studies should assess the generalizability of the findings in more ethnically and geographically diverse populations

Seven patients received probenecid (25 mg/kg load, then 10 mg/kg/dose q6h 11 doses) and NAC (140 mg/kg load, then 70 mg/kg/dose q4h 17 doses), and 7 received placebos via naso/orogastric tube

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