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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

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After the drug program ended, the compound was repositioned by its sponsor as a metabolic-health ingredient, supported by a self-affirmed generally recognized as safe (GRAS) characterization and safety/metabolism publications

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