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Description
Due to the small size and high surface area to volume ratio (SVR) of the NPs, they could easily cross the biological hurdles, like the blood-brain barrier (BBB) (20, 21)
A typical IgG1 antibody has roughly 90 lysine residues, of which approximately 30 can be modified under forcing conditions ( Random conjugation utilizing lysine generates a heterogeneous mixture of conjugate species (11)
If they give you hesitancy with that, then thats a red flag
David, L.A
