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The N-terminal PER moiety harbours most of the known functional domains, including two PER-ARNT-SIM (PAS) domains and an NLS sequence, but it lacks the CLK/CYC inhibition domain and thus does not replace endogenous PER function 27
Reduction in both neuronal NMDA activity and astrocytic kainate receptor-mediated glutamate signaling by mood-stabilizing agents has been noted to have antidepressant activity in bipolar disorder (261)
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Ann Rev Pharmacol Toxicol
