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10.1016/j.chembiol.2020.03.014 21 BeckmanJ

Radiation upregulates ACSL4 expression to induce ferroptosis, while GSTP1 overexpression reduces ACSL4 levels and increases GSH content, thereby enhancing cancer cell resistance to irradiation (131)

A deficiency can manifest gradually through chronic exhaustion, persistent fatigue, and noticeably slower recovery after physical or mental exertion [8]
