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897 Fat-soluble vitamin K2 (VK2) was also found to inhibit high glucose-mediated bone loss and ferroptosis, restore bone mass, and enhance the expression of osteogenic markers in the distal femur

Furthermore, GPX activity is dramatically reduced in smokers and those with COPD, underlining its essential function in lung antioxidant defenses

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In any case, the most commonly shared hallmark of different forms of cholestasis is an interruption of the enterohepatic circulation of bile acids and consequent retention of toxic bile salts in the bloodstream and at the intracellular level, leading to fibrosis and cirrhosis [173]