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coli at 150 g/mL, Salmonella typhimurium at 336 g/mL, and Pseudomonas aeruginosa at 228 g/mL

The mechanism by which metformin leads to apoptosis through cell cycle arrest can be explained as follows: when cells are blocked at specific cycle stages, they are unable to complete the normal process of DNA replication and division, resulting in increased intracellular pressure and accumulation of DNA damage, and these changes ultimately trigger the cells apoptosis program (63)

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