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Notably, natural products counteract hypoxia-induced oxidative stress damage by scavenging free radicals (such as ROS), up-regulating the activity of antioxidant systems (including SOD and GSH), blocking Ca 2+ inward flow, and modifying signaling pathways (including Nrf2/HO-1, NF-B, MAPK, Peroxiredoxin 6 [Prdx6])
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PMID: 27847966 | doi:10.1007/s00109-016-1488-y Seiwerth S et al
Dunn, A
