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5 TCM targets the gut microbiota and inflammatory pathways to treat depression Figure 4 shows a schematic diagram that shows how traditional Chinese medicine can be used to target the gut microbiota and inflammatory pathways to treat depression

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Notably, when the TET enzyme was knocked down, NF-B binding to the Rac1 promoter and Rac1 expression were suppressed, effectively preventing apoptosis in capillary cells ( Oxidative stress regulates inflammatory signaling pathways by selectively oxidizing NF-B through ROS, thereby modulating the expression of inflammatory factors (Warnatsch et al., 2017)