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Associated with ageing is also a loss of axons from RGCs, quantified in post-mortem human retinal sections at approximately 30007000 axons per year (Harwerth et al., 2008
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A detailed study revealed that polyphenols not only significantly increased intracellular ROS levels but also induced the upregulation of intracellular apoptotic stimulants, such as caspase-3, an important protease that plays a key role in apoptosis
