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doi: 10.1093/infdis/jiaa676, 55 LaworeD
The N-terminus and His-13 are crucial for Cu 2+ binding, and His-6 and His-14 are also implicated
For example, the R36Q and V44M mutations result in a bioinactive IGF-I where the patient produces IGF-I, but the IGF-I is incapable of binding with or has very low affinity for the IGF-I receptor, and therefore is relatively bioinactive
Certain health conditions that affect the gut, like Crohns or celiac disease, can also make absorption a major challenge
