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Another very important source of ROS, including hydrogen peroxide and superoxide anion radicals are dynamic and metabolically active subcellular compartments, peroxisomes (Phaniendra et al

doi: 10.1080/10715769900300721 139 ZieglerDAmetovABarinovADyckPJGurievaILowPAet al

Plant Physiol 142:775787 Cheng F, Yin LL, Zhou J, Xia-Jian X, Shi K, Yu JQ, Zhou YH, Foyer CH (2016) Interactions between 2-cys peroxiredoxins and ascorbate in autophagosome formation during the heat stress response in Solanum lycopersicum

Once folic acid is a precursor in de novo synthesis of thymidine, MTX imbalances nucleotide pools, ultimately leading to incorrect DNA synthesis and halting cell division
