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They revealed that activation of the MAPK pathway by ROS generated during ferroptosis could activate the transcription factor TFEB, which in turn induced the expression of genes involved in lysosomal biogenesis and autophagy

Cost-effectiveness Cost-effectiveness continues to be a key issue, as the raw materials (such as high-purity phospholipids and cholesterol), sterile manufacturing facilities, and specialised machinery considerably increase production costs relative to traditional formulations

[DOI] [PubMed] [Google Scholar] 272.Dirven H., Vist G.E., Bandhakavi S., Mehta J., Fitch S.E., Pound P., Ram R., Kincaid B., Leenaars C.H.C., Chen M., et al

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