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So the practical takeaway is not oral is better or SC is better. It is: pick one route, follow the documented per-dose figure for the vial you have, and keep the route constant so that whatever you observe is not confounded by a mid-stream route change

A subsequent trial with similar design, administering 24 IU IN-OXT or placebo in GSAD patients and healthy matched controls [191,192], found that IN-OXT enhanced functional connectivity between the amygdala, bilateral insula, and middle cingulate/dorsal anterior cingulate gyrus in response to fearful faces, in individuals with GSAD only [191]

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Hydrophobic or charged hydrophilic molecules diffuse poorly through mucus, while uncharged hydrophilic molecules can move quickly through the mucin mesh, with smaller molecules moving almost as fast as water