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Description
The ototoxicity of cisplatin occurs in 2350% of adults and up to 60% of children

The guanidyl group of Arg132 helps stabilize the pentavalent transition state that yields the acyl-phosphate intermediate

However, if the UPR fails to control the homeostasis of cells in response to ER stress, apoptosis is induced

Mitochondria-targeted FFa (Mito-FFa) increases the production of mtROS that triggers endoplasmic reticulum (ER) stress, and also oxidizes mtDNA and promotes its leakage into the cytoplasm
