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246 In a meta-analysis of 14 randomized controlled trials including 766 participants, green coffee extract at dosages ranging from 90 to 6,000 mg/day (providing 13.5 to 1,200 mg/day CGA) for up to 16 weeks lowered serum total cholesterol

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investigated for selective fat-mobilising effects independent of GH receptor signalling Cartilage & joint research Examined in chondrocyte models and osteoarthritis frameworks for anabolic effects on cartilage matrix synthesis Metabolic profile Investigated for absence of the hyperglycaemic and IGF-1-elevating effects associated with full-length hGH, making it a useful tool compound for isolating GHs metabolic effects Body composition models Studied in rodent obesity models for changes in fat mass, lean mass, and energy expenditure Clinical research history Progressed to early-phase human trials in Australia (2000s) for obesity and osteoarthritis indications

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