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The riskbenefit assessment for wellness or anti-aging interventions may differ substantially from that applied to disease-specific therapeutic indications, given the differing clinical objectives and risk tolerances

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Martnez-Lavn M

Along the aging, circadian rhythm is progressively perturbed and circulating IGF-1 level is reduced, resulting in defects in multiple systematic physiological functions (Tevy et al., 2013)

J Biol Chem 279:1798917995
