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The most established cause of lipid peroxidation is the regulation of cellular levels of glutathione (GSH) via the SLC7A11/xCT and the antioxidant enzyme glutathione peroxidase 4 (GPX4) axis

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It can cross the BBB and promote other drugs to enter the brain by regulating the permeability of the BBB and inhibiting the activity of P-gp [140]

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