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Phase IIa clinical trials were underway evaluating its capacity to reduce body fat without the diabetogenic or growth-promoting side effects of full-length hGH (Curr Opin Investig Drugs, 2004)

Despite the inclusion of newer trials with neutral findings, the analysis found colchicine reduced the rate of heart attack by 29%, stroke by 37%, and urgent revascularization procedures by 33%, as well as major cardiovascular events overall by 25%

For researchers using oral capsules, taking the compound 30 to 60 minutes before meals in a fasted state may enhance fat oxidation effects, though this recommendation is based on theoretical considerations rather than controlled studies