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first showed that hMLH1 may be methylated in peripheral blood, as well as in tumor tissue, in patients with colorectal cancer [32], based on a study in 14 patients with suspected Lynch syndrome with MSI

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28,29,30 NOX-mediated ROS broadly and specifically regulate various redox-sensitive signaling pathways involved in cancer progression via stimulating oncogenes, such as Src and Ras, and inactivating tumor suppressor proteins, such as TP53 and PTEN

Enzyme linked Immuno-sorbent assay (ELISA) kits for tumour necrosis factor-alpha (TNF-) quantification and NF-kb binding activity was purchased from Cayman chemicals, USA