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Kynurenine production insufficiency theory Recent research has identified the aryl hydrocarbon receptor (AhR) and the enzyme indoleamine-2,3-dioxygenase (IDO) as key players in the increased gut permeability and bacterial endotoxin translocation seen in ME/CFS patients

The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors

These observations indicate that light conditions may also control the glutathione-dependent subcellular redox environment at the transcriptional level

NAC has been used as a drug and a supplement, and the FDA reacted to what it considered overly aggressive marketing from hangover supplement brands that claimed NAC could treat conditions it hadnt been approved for by regulatory bodies