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doi: 10.1016/j.jhepr.2019.07.002

Because MTHFR gene variations impair the bodys ability to convert B vitamins, methylated forms of B vitamins are considered the most bioavailable as they dont need any conversion by the body Consider high doses: you might need significant doses of methylcobalamin to treat a deficiency

Pregnant and lactating women should ensure they are getting enough B12 through diet or supplements to support their health and that of their children
The truncated Bid interacts with Bax and Bad and permeabilizes the mitochondrial membrane, freeing cytochrome c or AIF (Broughton et al., 2009)
