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Neuroinflammation is actively involved in the pathogenesis of the disease, which is exhibited by the activation of glial cells, particularly astrocytes and microglia (Chen and Guilarte 2008
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Additionally, a relatively low SHBG, a slow reflex relaxation time, a low resting metabolic rate (metabolism), and a low basal body temperature can also be useful indicators of low tissue thyroid levels and can aid in the diagnosis of tissue hypothyroidism
