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The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling

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Both AOD 9604 and tirzepatide have been through human trials, but the depth and outcome of those trials could not be more different

2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis