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Accumulation of cytosolic succinate results the inhibition of the 2-oxoglutarate and Fe 2+ -dependent dioxygenases [prolyl hydroxylase domain (PDH) enzymes] responsible for the hydroxylation of the -subunit (HIF-1) of HIF-1

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Sadri, B

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acknowledges support from the Canadian Institutes of Health Research (RN192747-298730) and Diabetes Canada (RN271389-OG-3-15-5025-DZ)

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CamKinase II activity has been proposed to be a mechanism associated with regulating repetitive, involuntary, and obsessive behaviors in psychiatric disease 100 , suggesting that BT could have a potential role in modulating these ASD-associated behaviors

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