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Prescott[43] has suggested that increased APAP toxicity in the presence of alcohol may occur only when the liver is already compromised by other factors
Therefore, the debate between a B12 shot vs pill isn't a one-size-fits-all scenario

Akshintala S, Sundby RT, Bernstein D, Glod JW, Kaplan RN, Yohe ME et al
In addition to the application of the intranasal delivery method, the enrichment of therapeutics at the sub-mitochondrial site of action can reduce deleterious effects and increase therapeutic potency
