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Description
It incorporates key modifications, including 14E/17R mutations to stabilize an -helical segment via a salt bridge, multiple proline substitutions (25P, 28P, 29P) to reduce -sheet formation, and N-terminal C20 fatty diacid lipidation for reversible albumin binding (Kruse et al
The 5-year relative survival (2018-2022) was 72.9%, contributing to over 2.59 million prevalent cases in 2022
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