glutathione research emphysema Mucoactive and antioxidant medicines for COPD: consensus of a group of Chinese pulmonary physicians Lung glutathione and oxidative stress:

Increasing expression of GST-pi MIF, and ID1 genes in chemoresistant prostate cancer cells

Studies finding protective effects against cancer: A meta-analysis found that two copies of the C677T variant (AA genotype) decrease the risk of colon cancer by about 20%![ref] Another meta-analysis found that two copies of the C677T variant (AA genotype) were protective against prostate cancer .[ref] The MTHFR C677T variant decreases the relative risk of retinoblastoma and oral squamous cell cancer.[ref][ref] Two copies of the C677T variant (AA genotype) are protective against gastric cancer.[ref] However, for someone who has cancer, the MTHFR C677T variant is associated with poorer outcomes.[ref] The MTHFR A1298C variant (GG or GT) is associated with a decreased risk of hypothyroidism .[ref] The flip side: Folate can also help protect against cancerous mutations in the first place

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts