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A 2025 systematic review in orthopedic sports medicine concluded that BPC-157 promotes healing by boosting growth factors and reducing inflammation, with improved structural and functional recovery across fracture, muscle, tendon, and ligament injury models

However, when detecting the recycling of D2R to the cell surface following agonist-induced endocytosis, the GRK (-) receptor exhibited less recycling than the WT receptor, indicating that phosphorylation can facilitate receptor recycling

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