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10.1016/j.cell.2012.11.024 105 LuoM.ZhaoF.ChengH.SuM.WangY

McDaniel JC, Browning KK

Instead, under these lactate-rich conditions, the highly expressed NAMPT utilizes an alternative signaling capacity to enhance immunosuppressive phenotype of TAMs through the HIF-1/STAT3 signaling pathway 23 , while preventing the utilization of salvaged NAD + for the glycolytic demands of an IFN-mediated inflammatory response 85

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