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Nat Rev Immunol 14, 302314 (2014)
TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA
Jung J, Hermanns-Clausen M, Weinmann W
The other option if you don't want to boost the current is to parallel charge
